Acute fatty liver of pregnancy is a life-threatening rare complication of pregnancy which occurs immediately after delivery or in the third trimester. It is caused by disordered metabolism of fatty acids by mitochondria in mother which is caused by 3-hydroxyacylcoemzyne A dehydrogenase deficiency. Earlier this complication was considered to be a fatal condition, but with advanced treatment procedures it is possible to stabilize pregnant females with the interventions of intravenous fluids and blood products in anticipation of preterm delivery has improved prognosis.
How does acute Fatty Liver of Pregnancy develop?
Acute Fatty Liver of Pregnancy develops in the mothers who are carrying fetus or fetuses who are having a genetic disorder which leads to defective mitochondria beta-oxidation of fatty acids. In other words, the powerhouse of cells which is mitochondria is not breaking down the fatty acids in smaller molecules which further helps in body process lipids, carbohydrates, and proteins.
Due to this genetic issue, it causes the accumulation of fat in the liver cells and also in placenta, kidney and other sites. Due to the accumulation of fatty acids in tissues, this clogs the liver of the mother and leads to the interference with normal functioning of the liver of the women carrying a baby. A healthy liver is very important for any pregnant lady as it removes all the toxins and harmful substance from the body.
Signs and symptoms associated with Fatty Liver of Pregnancy:
Due to malfunctioning of the liver, it makes healthy pregnant women come into the non-healthy and sick state. Common and frequent symptoms of the acute fatty liver of pregnancy are:
- Loss of appetite
- Vomiting and nausea
- Abdominal pain
These symptoms are usually recognized when these symptoms are very persistent during advanced acute fatty liver of pregnancy. The disease is rare so it is difficult to diagnose. Due to loss of normal liver function which leads to increase in acid build up also leads to change in the mental status of mother and also compromises with her baby’s well being.